Big Ten opponents meet when the No. 1 Ohio State Buckeyes (7-0) and the Penn State Nittany Lions (3-4) square off on Saturday, November 1, 2025 at Ohio Stadium.
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Ohio State vs. Penn State Matchup Info
- Game date: Saturday, November 1, 2025
- Game time: 12 p.m. ET
- Location: Columbus, Ohio
- Venue: Ohio Stadium
- TV channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Ohio State vs. Penn State Odds and Prediction
- Spread favorite: Buckeyes (-19.5)
- Moneyline: Buckeyes (-1408), Nittany Lions (+836)
- Total: 44.5 points
- Pick ATS: Ohio State (-19.5)
- Pick OU: Over (44.5)
- Prediction: Ohio State 38, Penn State 8
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Ohio State vs. Penn State Betting Records and Insights
- Ohio State has put together a 6-1-0 ATS record so far this year.
- Penn State has won just one game against the spread this year.
- The Buckeyes have an ATS record of 3-1 when playing as at least 19.5-point favorites this season.
- This season, games featuring the Ohio State have hit the over twice.
- Penn State and its opponent have combined to hit the over five out of seven times this season.