Iowa vs. Penn State Football Prediction & Odds - Oct. 18

The Iowa Hawkeyes (4-2) meet a conference opponent when they host the Penn State Nittany Lions (3-3) on Saturday, October 18, 2025 at Kinnick Stadium in a Big Ten battle.

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Iowa vs. Penn State Matchup Info

  • Game date: Saturday, October 18, 2025
  • Game time: 7 p.m. ET
  • Location: Iowa City, Iowa
  • Venue: Kinnick Stadium
  • TV channel: Peacock

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Iowa vs. Penn State Odds and Prediction

  • Spread favorite: Hawkeyes (-3)
  • Moneyline: Hawkeyes (-158), Nittany Lions (+133)
  • Total: 40.5 points
  • Pick ATS: Iowa (-3)
  • Pick OU: Over (40.5)
  • Prediction: Iowa 34, Penn State 15

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa vs. Penn State Betting Records and Insights

  • Iowa has won four games against the spread this season, while failing to cover or pushing twice.
  • Penn State has not won against the spread this year in six chances.
  • The Hawkeyes have been favored by 3 points or more three times this season, and covered the spread in two of those matchups.
  • Iowa games have hit the over twice this season.
  • So far this year, four of Penn State's six games with a set number have gone over the point total.

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